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The Antibody and Autoantibody Seromics Revolution

With over 21,000 full-length human proteins, the HuProt™ microarray is the world's largest and most comprehensive collection of thoroughly validated proteins.

HUPROT MICROARRAY
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HuProt™ Proteome Microarray contains

Over 21,000 GST-purified Full-length Proteins

HuProt is quality confirmed with anti-GST QA/QC. Successful folding has been demonstrated by kinase autophosphorylation assay.

HUPROT MICROARRAY
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VirScan™ - Viral PhIP-Seq Antibody Profiling Services

Most Vertebrate Viral Proteomes in a Single Assay

Most vertebrate viral proteomes epitope-level autoantibody profiling service via T7 phage display and immunoprecipitation sequencing (PhIP-Seq).

VIRSCAN PHIP-SEQ
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CDI Labs Autoantibody Profiling Services

High-throughput Autoantibody Signature Validation

CDI Labs offers high-throughput focused array services to validate autoantibody signatures discovered with the HuProt Microarray.

HUPROT SERVICES

The World's Most Comprehensive Portfolio for Autoantibody Detection

Transformational products and services for proteome-wide autoantibody profiling, biomarker discovery, cross-reactivity screening, and other whole-proteome target identification and interaction assays

We Offer the Most Powerful Antigen Libraries

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21,000+ Full-length Proteins

GST-purified and validated recombinant proteins and isoform variants

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Cell Membrane-embedded

Purified virion display correctly-folded membrane-embedded GPCRs

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Most Vertebrate Viral Proteomes

Detects antibodies against 68,000+ vertebrate viral protein sequences

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All Human Proteome

Detects antibodies against 48,921 unique human proteins and protein isoforms

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All Murine Proteome

Detects antibodies against 50,135 unique murine proteins and protein isoforms

CDI Labs CanadaCanada FlagVirScan, HuScan and MouseScan are provided exclusively by CDI Labs Canada.

CDI Labs Autoantibody Seromics

The serome is the total secreted antibody repertoire of a single individual; each serome is unique and created by a person's lifetime of adaptive immune experiences. The goal of the emerging scientific field of 'autoantibody seromics' is to understand the largest impacts of the serome on human health, disease, and clinical outcomes.

More Content and Better Data

We start with sequence-confirmed plasmids, then individually express and GST-purify proteins from S. cerevisiae. Piezolelectric printing is used to spot these in duplicate alongside controls. Quality is confirmed with anti-GST QA/QC. Successful folding demonstrated by kinase autophosphorylation assay.

PUBLICATIONS

220+peer-reviewed publications

With over 220 publications (and growing), our antibody seromics solutions and HuProt array continue to play a key role in life sciences by contributing to critical studies that help accelerate research, advance discoveries, and translate discoveries to novel products that improve human health.

CUSTOMER-BASE

190+customer base

Our customer base continues to expand throughout North America, Europe, and Asia Pacific, and is a testament to the quality and consistency of our products and services.

FOUNDERS

Boeke, Zhu & Blackshawat Johns Hopkins University

Funded by NIH Common Fund Support for the Development of Protein Capture Reagents and Technologies, the HuProt Protein Microarray was created by CDI Labs co-founders Jef Boeke, Heng Zhu, Dan Eichinger, and Seth Blackshaw, faculty members at the High Throughput Biology (HIT) Center at the Johns Hopkins University School of Medicine.

Data and technology validated by scientists

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

OncologistSchool of Medicine Research (as mentioned in "Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade" - AACR Clinical Caner Research - September 2022)

Data and technology validated by scientists

"This (VirScan) assay, which uses phage display immunoprecipitation and sequencing, is a sensitive and focused high-comprehensive approach that enables thorough serological profiling of antiviral antibodies in humans and, consequently, the identification of viral exposure throughout the human virome."

Faculty of MedicineResearch Institution (as mentioned in "Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC" - Science Advances - November 2023)

Data and technology validated by scientists

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Senior ScientistBiotech Research (poster presentation at the San Antonio Breast Cancer Symposium 2023)

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  • Mar 19
  • |
  • 2018
Nature Methods

HuProt: A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors

Anand Venkataraman, Blackshaw Seth, et. al.

on Nature Methods
  • Feb 22
  • |
  • 2023
Nature

HuProt: Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells

Louise Malle, Dusan Bogunovic, et. al.

on Nature
  • Sep 15
  • |
  • 2022
AACR - Clinical Cancer Research

HuProt: Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade

Paul Johannet, Iman Osman, et. al.

on AACR - Clinical Cancer Research
  • Nov 8
  • |
  • 2023
Science Advances

VirScan: Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC

Marie Naigeon, Nathalie Chaput, et. al.

on Science Advances
  • Nov 8
  • |
  • 2023
Nature

HuProt: Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Tom Le Voyer, Anne Puel, et. al.

on Nature
  • Apr 13
  • |
  • 2022
Nature Scientific Reports

HuProt: Temporal reproducibility of IgG and IgM autoantibodies in serum from healthy women

T. V. Clendenen, Y. Chen, et. al.

on Nature Scientific Reports
  • Feb 3
  • |
  • 2021
Nature

HuProt: IgA transcytosis and antigen recognition govern ovarian cancer immunity

Subir Biswas, Jose R. Conejo-Garcia, et. al.

on Nature
  • Aug 2
  • |
  • 2023
CISION PR Newswire

Press Release

Barney E. Saunders Ph.D. has been appointed Chief Executive Officer of CDI Laboratories

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  • Jan 9
  • |
  • 2023
CISION PR Newswire

Press Release

BroadOak Capital Partners Invests in CDI Laboratories to Expand and Scale Antibody Biomarker Discovery Platforms

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  • Sep 23
  • |
  • 2020
CISION PR Newswire

Press Release

CDI Labs HuProt™ Protein Arrays Instrumental in Recent Study of Multisystem Inflammatory Syndrome in Children (MIS-C)

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  • Feb 4
  • |
  • 2020
CISION PR Newswire

Press Release

CDI Labs Launches Two New Powerful Assays to its Biomarker Discovery Platform

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  • Mar 6
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  • 2019
CISION PR Newswire

Press Release

CDI Labs to showcase immuno-oncology products & services at AACR 2019

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  • Mar 5
  • |
  • 2019
CISION PR Newswire

Press Release

CDI Labs Releases HuProt™ v4.0 - Adding additional content to Largest Content Human Proteome Microarray in the World

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  • Apr 19
  • |
  • 2018
News is My Business

News

CDI Laboratories Inc. Opens $17M Biotech Lab in Mayagüez

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  • Mar 28
  • |
  • 2018
CISION PR Newswire

Press Release

CDI Labs' Monoclonal Antibody Development Pipeline featured in Nature Methods

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  • Mar 8
  • |
  • 2018
BioSpace

Press Release

CDI Labs Collaborates on Discovery of New Biomarkers for Zika Infection

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  • Nov 28
  • |
  • 2017
CISION PR Newswire

Press Release

CDI Labs Cites New Research Identifying Early Lung Cancer Autoantibody Biomarkers using HuProt™

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  • Nov 1
  • |
  • 2017
Technology Networks - Proteomics and Metabolomics

News

The World's Largest Human Proteome Microarray: Advancing Protein Biomarker Discovery

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  • May 25
  • |
  • 2017
CISION PR Newswire

Press Release

CDI Labs Expands HuProt™ - The Highest Content Human Proteome Microarray in the World

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  • Apr 17
  • |
  • 2017
CISION PR Newswire

Press Release

CDI Laboratories and NeoBiotechnologies Form Alliance to Distribute CDI's 2500 Monospecific Transcription Factor Antibodies

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Events

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CONFERENCE

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  • Jun 21
  • San Francisco
FOCIS 2024

FOCIS 2024

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  • Jun 18
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  • Jun 18
  • Boston
Immuno-Oncology Xchange (Boston)

Immuno-Oncology Xchange (Boston)

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CONFERENCE

  • Nov 6
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  • Nov 10
  • Houston
sitc 2024

sitc 2024

Booth CDI Labs
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