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The world’s most comprehensive content to power

The Autoantibody and Antibody Seromics Revolution

With over 21,000 full-length, correctly-folded 3D human proteins, the HuProt™ microarray is the world's largest and most comprehensive collection of thoroughly validated proteins.

HUPROT MICROARRAY
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HuProt™ Proteome Microarray contains

21,000+ Full-length, Correctly-folded 3D Proteins

HuProt is quality confirmed with anti-GST QA/QC. Successful folding has been demonstrated by kinase autophosphorylation assay.

HUPROT MICROARRAY
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VirScan® - Viral PhIP-Seq Antibody Profiling Services

Most Vertebrate Viral Proteomes in a Single Assay

Most vertebrate viral proteomes epitope-level autoantibody profiling service via T7 phage display and immunoprecipitation sequencing (PhIP-Seq).

VIRSCAN PHIP-SEQ

The World's Most Comprehensive Portfolio and Content for Autoantibody Detection

Transformational products and services for proteome-wide autoantibody profiling, biomarker discovery, cross-reactivity screening, and other whole-proteome target identification and interaction assays

We Offer the Most Powerful Antigen Libraries

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21,000+ Full-length Proteins

Correctly-folded, GST-purified recombinant proteins and isoform variants

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Cell Membrane-embedded

Purified virion display correctly-folded membrane-embedded GPCRs

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Most Vertebrate Viral Proteomes

Detects antibodies against 68,000+ vertebrate viral protein sequences

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All Human Proteome

Detects antibodies against 48,921 unique human proteins and protein isoforms

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All Murine Proteome

Detects antibodies against 50,135 unique murine proteins and protein isoforms

CDI Labs CanadaCanada FlagVirScan, HuScan and MouseScan are provided exclusively by CDI Labs Canada.

CDI Labs Autoantibody Seromics

The serome is the total secreted antibody repertoire of a single individual; each serome is unique and created by a person's lifetime of adaptive immune experiences. The goal of the emerging scientific field of 'autoantibody seromics' is to understand the largest impacts of the serome on human health, disease, and clinical outcomes.

PUBLICATION HIGHLIGHT

A causal link between autoantibodies and neurological symptoms in long COVID

AUTHORS

Keyla Santos Guedes de Sa, Julio Silva, Rafael Bavarri-Olmos, Ran Brinda, Robert Alec Rath Constable, Patricia A. Colom Diaz, Donq-il Kwon, Gisele Rodriques, Li Wenxue, Christopher Baker, Bornali Bhattachariee, Jamie Wood, Laura Tabacof, Yanshena Liu, David Putrino, Tamas L. Horvath, Akiko Iwasaki

ABSTRACT

Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated autoantibodies have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified diverse AAB targets in LC patients that correlated with their symptoms. Elevated AABs to proteins in the nervous system were found in LC patients with neurocognitive and neurological symptoms. Purified Immunoglobulin G(IgG) samples from these individuals reacted with human pons tissue and were cross-reactive with mouse sciatic nerves, spinal cord, and meninges. Antibody reactivity to sciatic nerves and meninges correlated with patient-reported headache and disorientation. Passive transfer of IgG from patients to mice led to increased sensitivity and pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance and coordination, reflecting donor-reported dizziness. Our findings suggest that targeting AABs could benefit some LC patients.

More Content and Better Data

We start with sequence-confirmed plasmids, then individually express and GST-purify proteins from S. cerevisiae. Piezolelectric printing is used to spot these in duplicate alongside controls. Quality is confirmed with anti-GST QA/QC. Successful folding demonstrated by kinase autophosphorylation assay.

PUBLICATIONS

220+peer-reviewed publications

With over 220 publications (and growing), our antibody seromics solutions and HuProt array continue to play a key role in life sciences by contributing to critical studies that help accelerate research, advance discoveries, and translate discoveries to novel products that improve human health.

CUSTOMER-BASE

190+customer base

Our customer base continues to expand throughout North America, Europe, and Asia Pacific, and is a testament to the quality and consistency of our products and services.

FOUNDERS

Boeke, Zhu & Blackshawat Johns Hopkins University

Funded by NIH Common Fund Support for the Development of Protein Capture Reagents and Technologies, the HuProt Protein Microarray was created by CDI Labs co-founders Jef Boeke, Heng Zhu, Dan Eichinger, and Seth Blackshaw, faculty members at the High Throughput Biology (HIT) Center at the Johns Hopkins University School of Medicine.

Data and technology validated by scientists

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

OncologistSchool of Medicine Research (as mentioned in "Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade" - AACR Clinical Caner Research - September 2022)

Data and technology validated by scientists

"This (VirScan) assay, which uses phage display immunoprecipitation and sequencing, is a sensitive and focused high-comprehensive approach that enables thorough serological profiling of antiviral antibodies in humans and, consequently, the identification of viral exposure throughout the human virome."

Faculty of MedicineResearch Institution (as mentioned in "Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC" - Science Advances - November 2023)

Data and technology validated by scientists

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Senior ScientistBiotech Research (poster presentation at the San Antonio Breast Cancer Symposium 2023)

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  • Mar 19
  • |
  • 2018
Nature Methods

A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors

Anand Venkataraman, Blackshaw Seth, et. al.

on Nature Methods
  • Feb 22
  • |
  • 2023
Nature

Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells

Louise Malle, Dusan Bogunovic, et. al.

on Nature
  • Sep 15
  • |
  • 2022
AACR - Clinical Cancer Research

Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade

Paul Johannet, Iman Osman, et. al.

on AACR - Clinical Cancer Research
  • Nov 8
  • |
  • 2023
Science Advances

Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC

Marie Naigeon, Nathalie Chaput, et. al.

on Science Advances
  • Nov 8
  • |
  • 2023
Nature

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Tom Le Voyer, Anne Puel, et. al.

on Nature
  • Apr 13
  • |
  • 2022
Nature Scientific Reports

Temporal reproducibility of IgG and IgM autoantibodies in serum from healthy women

T. V. Clendenen, Y. Chen, et. al.

on Nature Scientific Reports
  • Feb 3
  • |
  • 2021
Nature

IgA transcytosis and antigen recognition govern ovarian cancer immunity

Subir Biswas, Jose R. Conejo-Garcia, et. al.

on Nature
  • Jun 19
  • |
  • 2024
medRxiv

A causal link between autoantibodies and neurological symptoms in long COVID

Keyla Santos Guedes de Sa, Julio Silva, Rafael Bayarri-Olmos, Ryan Brinda, Robert Alec Rath Constable, Patricia A. Colom Diaz, Dong-il Kwon, Gisele Rodrigues, Li Wenxue, Christopher Baker, Bornali Bhattacharjee, Jamie Wood, Laura Tabacof, Yansheng Liu, David Putrino, Tamas L. Horvath, Akiko Iwasaki

on medRxiv
  • Jul 9
  • |
  • 2024
CISION PR Newswire

Press Release

CDI Labs Launches New VirScan, HuScan, and MouseScan Services for Massively Multiplexed Analysis of Serum Antibodies

Read More
  • Aug 2
  • |
  • 2023
CISION PR Newswire

Press Release

Barney E. Saunders Ph.D. has been appointed Chief Executive Officer of CDI Laboratories

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  • Jan 9
  • |
  • 2023
CISION PR Newswire

Press Release

BroadOak Capital Partners Invests in CDI Laboratories to Expand and Scale Antibody Biomarker Discovery Platforms

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  • Sep 23
  • |
  • 2020
CISION PR Newswire

Press Release

CDI Labs HuProt™ Protein Arrays Instrumental in Recent Study of Multisystem Inflammatory Syndrome in Children (MIS-C)

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  • Feb 4
  • |
  • 2020
CISION PR Newswire

Press Release

CDI Labs Launches Two New Powerful Assays to its Biomarker Discovery Platform

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  • Mar 6
  • |
  • 2019
CISION PR Newswire

Press Release

CDI Labs to showcase immuno-oncology products & services at AACR 2019

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  • Mar 5
  • |
  • 2019
CISION PR Newswire

Press Release

CDI Labs Releases HuProt™ v4.0 - Adding additional content to Largest Content Human Proteome Microarray in the World

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  • Apr 19
  • |
  • 2018
News is My Business

News

CDI Laboratories Inc. Opens $17M Biotech Lab in Mayagüez

Read More
  • Mar 28
  • |
  • 2018
CISION PR Newswire

Press Release

CDI Labs' Monoclonal Antibody Development Pipeline featured in Nature Methods

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  • Mar 8
  • |
  • 2018
BioSpace

Press Release

CDI Labs Collaborates on Discovery of New Biomarkers for Zika Infection

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  • Nov 28
  • |
  • 2017
CISION PR Newswire

Press Release

CDI Labs Cites New Research Identifying Early Lung Cancer Autoantibody Biomarkers using HuProt™

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  • Nov 1
  • |
  • 2017
Technology Networks - Proteomics and Metabolomics

News

The World's Largest Human Proteome Microarray: Advancing Protein Biomarker Discovery

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  • May 25
  • |
  • 2017
CISION PR Newswire

Press Release

CDI Labs Expands HuProt™ - The Highest Content Human Proteome Microarray in the World

Read More
  • Apr 17
  • |
  • 2017
CISION PR Newswire

Press Release

CDI Laboratories and NeoBiotechnologies Form Alliance to Distribute CDI's 2500 Monospecific Transcription Factor Antibodies

Read More

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  • Nov 10
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sitc 2024

sitc 2024

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