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VirD™ Functional Membrane Protein Virion Display Microarray
Revolutionary viral-based expression technology for functional membrane protein analysis with unprecedented accuracy
REQUEST INFOG protein-coupled receptors (GPCRs) and membrane proteins are notoriously difficult to study due to their complex folding requirements and membrane dependencies. Traditional expression systems often fail to produce functional proteins.
VirD™ technology overcomes these limitations by utilizing a sophisticated viral-based expression system that maintains protein functionality while enabling high-throughput analysis on microarray platforms.
VirD is a microarray that uses virions to display functional membrane proteins like GPCRs and is useful for drug development and functional assays.
VirD membrane protein technology has a range of applications across various fields in life sciences and biotechnology. Here are some key applications:
Drug Discovery and Development
Identify and characterize potential drug targets, particularly membrane proteins like G protein-coupled receptors (GPCRs), ion channels, and transporters.
Biomarker Discovery
Discover and characterize membrane proteins that serve as biomarkers for diseases, i.e., cancer research and diagnostics, where specific membrane proteins may indicate disease presence or progression.
Protein Interaction Studies
Investigate protein-protein interactions involving membrane proteins – critical for understanding signaling pathways and cellular communications.
Therapeutics Production
Produce therapeutic proteins, including antibody fragments or fusion proteins that target membrane proteins, enhancing the potential for novel treatments.
Functional Characterization
Study the functional properties of membrane proteins in native-like environments; assess how these proteins interact with ligands, their conformational changes, and their role in cellular processes.
Choosing VirD membrane protein technology offers several compelling advantages that make it an attractive option for researchers and companies involved in the study and application of membrane proteins. Here are some key reasons:
Proper Protein Folding
Our patented viral-based expression system ensures GPCRs and membrane proteins maintain their native conformation and functionality, embedded in authentic cell membranes.
Eliminates Interference
Unlike traditional cell-based systems, VirD microarrays eliminate endogenous receptor competition, providing cleaner, more interpretable experimental data.
High-throughput Analysis
Microarray format enables simultaneous analysis of multiple GPCRs and membrane proteins, accelerating drug discovery and functional studies.
Validated Drug Targets
Focus on clinically relevant GPCRs and membrane proteins that are critical for drug development and therapeutic intervention.
Drug Discovery
VirD plays a critical role in early-stage drug discovery, especially for therapeutics targeting membrane proteins which are important drug targets.