Diagnostic Development

HuProt for the Diagnosis of Autoimmune Diseases

The presence of autoantibodies is often a key diagnostic criterion for autoimmune diseases

Autoantibodies are frequently detected in the serum or plasma of patients with a wide range of diseases, including autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus (SLE), autoimmune thyroid diseases (e.g., Hashimoto's thyroiditis, Graves' disease), type 1 diabetes, and autoimmune liver diseases (e.g., autoimmune hepatitis, primary biliary cholangitis). The presence of specific autoantibodies is often a key diagnostic criterion for these diseases. Autoantibody panels consisting of several specific autoantibodies have the potential to be used for the diagnosis and classification of autoimmune diseases where diagnosis is challenging due to the heterogeneity of the clinical course, symptoms and severity of the disease.

In the featured publication below, HuProt™ microarray was used to profile autoantibodies in patients with systemic lupus erythematosus (SLE). Further analysis with a larger patient cohort using SLE-focused microarrays identified 31 autoantibodies with potential as biomarkers for diagnosis and 11 for differential diagnosis of SLE.