Scientific Publications

This study explores the therapeutic potential of Ponicidin on Lenvatinib-resistant hepatocellular carcinoma (HCC), elucidates its mechanism in reversing Lenvatinib resistance, and provides experimental evidence for its clinical application in overcoming this resistance.

• Link: https://www.sciencedirect.com/science/article/abs/pii/S0944711325004623?via%3Dihub

Gut microbial metabolites are recognised as critical effector molecules that influence the development of colorectal cancer (CRC). Peptidoglycan fragments (PGFs) produced by microbiota play a crucial role in maintaining intestinal homeostasis, but their role in CRC remains unclear.

• Link: https://gut.bmj.com/content/74/8/1230

The understanding of disease mechanisms and the search for potential therapeutic targets have driven the focus of proteomics studies towards the identification of specific protein profiles and molecular pathways disease associated. Protein microarrays offer high-throughput alternatives to mass spectrometry, with peptide, phage, and recombinant protein microarrays providing different options for studying disease-specific alterations. Commercially available antibody microarrays, particularly cytokine arrays, enable the simultaneous analysis of multiple cytokine expression levels, offering valuable insights into disease processes, drug efficacy, and biomarker discovery.

• Link: https://link.springer.com/protocol/10.1007/978-1-0716-4595-6_15

Melanoma-Associated Antigens (MAA) are correlated with tumor development, progression and metastatic dissemination. MAA can be targeted in immunotherapy by specific antibodies or by cytotoxic T-cells. MAA are actually self-antigens and, thus, are weak immunogens because they induce various degrees of immune tolerance. Four families of MAA are involved in clinical monitoring and therapy efficacy, such as: melanocyte lineage/differentiation antigens, oncofetal/cancer-testis antigens, GAGE antigens and the extended family of cell-adhesion receptors.

• Link: https://www.scribd.com/document/822609296/Antibodies-Against-Melanoma-Antigens-Clinical-and-Therapeutical-Markers

With the global prevalence of hypertension, diabetes, obesity and aging populations, there is also a steady increase in the incidence of chronic kidney diseases (CKD), affecting up to 10–15 % of the global population and posing a significant public health concern. In China, an estimated 130 million adults are affected by CKD (Kalantar-Zadeh et al., 2021; Zhang et al., 2016; Romagnani et al., 2025). CKD is pathologically characterized by renal fibrosis (RF) and will be progressed to end-stage renal disease (ESRD) regardless of its primary etiology. RF is manifested as excessive deposition of extracellular matrix (ECM), glomerulosclerosis, and tubular atrophy, which collectively contribute to the development of ESRD in patients with CKD.

• Link: https://www.sciencedirect.com/science/article/abs/pii/S0944711325006221?via%3Dihub

CA 15-3 and CA 27–29 are widely used serum biomarkers for breast cancer with limited utility due to low sensitivity in early-stage disease. This study details the discovery of BF-09, a new breast cancer marker with potential for wider application.

• Link: https://www.sciencedirect.com/science/article/pii/S2405580825001840?via%3Dihub

Monoamine oxidase A (MAO A) is a key enzyme for serotonin metabolism. Knockout MAO A in mice results in elevated serotonin, altered serum autoantibodies, and autistic-like behavior. There is a subset of patients with autism spectrum disorder (ASD) who exhibit hyperserotonemia. The link between the MAO A, hyperserotonemia, immunity, and ASD is still unknown. To address this question, we harness the high-density human proteome microarray to profile the serum autoantibodies in ASD patients with or without MAO A deficiency.

• Link: https://www.sciencedirect.com/science/article/pii/S2666354625000973?via%3Dihub

ICC is a malignant tumor that originates from the intrahepatic bile ducts with insidious symptoms and a poor prognosis. Early diagnosis methods and therapeutic targets are urgently needed for ICC.

• Link: https://jeccr.biomedcentral.com/articles/10.1186/s13046-025-03436-1

This study investigates HDAC3 as a potential immunotherapy biomarker in advanced non-small cell lung cancer (aNSCLC), focusing on its association with treatment response to immune checkpoint inhibitors (ICIs).

• Link: https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-025-03275-w

Endometrial cancer (EC) is a gynecological malignancy that originates from the endometrial epithelium and has a poor prognosis when advanced, recurrent, or metastatic. The limited therapeutic efficacy and severe adverse effects of conventional chemotherapy in advanced EC highlight the urgent need to develop more effective therapeutic drugs. Accumulating clinical evidence has revealed that natural compounds possess pharmacological advantages, including low toxicity and multi-target mechanisms. Erianin is a natural small-molecule compound isolated from Dendrobium chrysotoxum Lindl that has multiple pharmacological effects. However, the effects of erianin on EC have not been confirmed and its anticancer mechanisms remain unclear.

• Link: https://www.researchsquare.com/article/rs-6876152/v1