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Peptide Hormone PhIP-Seq Services
Transform Your Peptide Hormone Research
As part of our HuScan services, we are now offering our Peptide Hormone PhIP-Seq library services. Discover, quantify, and analyze peptide hormone interactions like never before.
REQUEST INFOAdvanced Services for Detecting Hormone-specific Autoantibodies
Unlock the Hidden Role of Hormone-targeting Autoantibodies in Health and Disease
The endocrine system controls critical physiological processes through peptide hormones, but emerging research reveals a crucial missing piece: circulating autoantibodies that bind directly to these hormones. Our innovative Peptide Hormone PhIP-Seq service provides the most comprehensive platform available for identifying these hormone-specific autoantibodies and their role in disease.
PhIP-Seq Methods and Analysis
HuScan PhIP-Seq enables simultaneous epitope-level autoantibody profiling against an entire human proteome.
Revolutionary PhIP-Seq Technology
Our Peptide Hormone PhIP-Seq service combines the power of phage display with next-generation sequencing to deliver unprecedented insights into hormone-targeting autoantibodies.
Due to the critical nature of these peptides and variations in phage display structure which might inhibit detection of an antibody response, each peptide hormone was displayed redundantly in multiple windowed contexts. Short hormones were displayed to the left, center, right, or repeated across the 34-mer peptide display window. Each version was displayed 5-times, providing abundant experimental redundancy for real detected reactions. An example of this for an insulin peptide is shown in the table below.
Peptide Hormone PhIP-Seq Library Design Strategy
An example of this for an insulin peptide is shown here.
Comprehensive Coverage and Unmatched Expertise
6,520 unique peptides
representing 356 hormone entries
290 human peptide hormones
plus 66 pharmaceutical preparations
Multiple display contexts
with 5-fold redundancy for maximum sensitivity
Epitope-level resolution
for precise antibody mapping
Proven validation
with commercial insulin antibodies and human serum samples
Why Hormone-targeting Autoantibodies Matter
Traditional approaches to hormonal disorders have focused on genetic, metabolic, and environmental factors. However, mounting evidence shows that autoantibodies reactive to peptide hormones play a significant role in:
Metabolic Disorders
Autoantibodies against appetite-regulating hormones linked to obesity, anorexia nervosa, and bulimia
Endocrine Dysfunction
Thyroid-targeting antibodies in Hashimoto's thyroiditis and Graves' disease
Neuropsychiatric Conditions
ACTH-reactive antibodies associated with aggression and conduct disorders
Growth and Development
IGF2 autoantibodies implicated in growth disorders and cancer
Reproductive Health
Autoantibodies targeting reproductive hormones like FSH, LH, and hCG contributing to infertility, polycystic ovary syndrome, and pregnancy complications
Why Choose CDI Labs?
As leaders in high-throughput serological screening, we combine cutting-edge technology with deep scientific expertise.
Our Peptide Hormone PhIP-Seq service represents the next generation of autoantibody detection, providing researchers with the tools needed to understand the complex interplay between hormones, immunity, and disease. Whether you're investigating metabolic disorders, autoimmune diseases, or exploring novel therapeutic targets, our hormone-focused PhIP-Seq platform delivers the comprehensive, high-resolution data you need to advance your research.
Unmatched Sensitivity
Our hormone-focused library provides superior detection compared to traditional one-by-one assays, with built-in redundancy ensuring reliable results.
Epitope-level Resolution
Precise mapping of antibody binding sites enables deeper understanding of autoantibody function and cross-reactivity patterns.
Proven Validation
Extensively validated with commercial insulin antibodies and human serum samples, demonstrating robust performance across diverse sample types.
Expert Analysis
Our team of scientists provides comprehensive data interpretation and supports your research goals with cutting-edge bioinformatics analysis.
Technical Excellence
Peptide Hormone PhIP-Seq services is integrated with HuScan® PhIP-Seq for proteome-wide analysis and is scalable for large cohort studies.
Ready to Transform Your Research?
Discover how Peptide Hormone PhIP-Seq can revolutionize your understanding of hormone-targeting autoantibodies
and accelerate your research breakthroughs.