VirScan PhIP-Seq: Comprehensive Viral Antibody Profiling | CDI Labs

Viral Exposure Profiling and Pathogen Surveillance

Phage Display ImmunoPrecipitation Sequencing (PhIP-Seq) is a powerful method of multiplexed analysis that combines DNA high-throughput sequencing with next-gen proteomics.

VirScan allows researchers to determine what antibodies were created by an individual’s unique history of viral exposures. PhIP-Seq is the highest-coverage antigen-specific assay yet developed, able to detect antibodies versus virtually any antigen via overlapping long peptides. VirScan enables simultaneous epitope-level autoantibody profiling versus most vertebrate viruses.

VirScan® PhIP-Seq Advantages

Enabling researcher to uncover both individual and population-level histories of viral infections

Viral exposure profiling and pathogen surveillance

Explore the connection between viral exposure and chronic disease

Identify key triggers that contribute to disease

Gain deeper insights to host-pathogen interactions and immune system's response to viral challenges

Identify and investigate instances of molecular mimicry

Identify events of molecular mimicry to better understand autoimmune reactions

Detect antibodies against over 68,000+ viral proteins

Gain deeper insights for autoimmune diseases, neurological disorders, and cancer

Discover how viruses may influence disease

Discover new epidemiological patterns and the dynamics of infectious disease

VirScan Technology Overview

Ready to Transform Your Research?

Discover how VirScan PhIP-Seq can revolutionize your understanding of immune responses
and accelerate your research breakthroughs.

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What Our Customers Are Saying

"With CDI Labs, identifying antibodies and their targets has never been so simple. Their passionate team, robust science and high-quality service unlock the discovery of new mechanisms, biomarkers and therapeutic targets."

Matthieu Roulleaux DugageGustave Roussy View poster, "Baseline serum level of IgG targeting annexin A2 is predictive of response to immunotherapy in patients with advanced NSCLC" presented at IMMUNOLOGY 2025

What Our Customers Are Saying

"We enjoyed working with CDI Labs. We used both VirScan and HuScan services from CDI Labs as part of our neurodegenerative disease research. The team at CDI Labs was very responsive and great to work with, and they went above and beyond to get us our results very quickly. They were particularly helpful in making contract arrangements and ensuring that everything was in place for a smooth collaboration. CDI Labs also provided a comprehensive statistical analysis, which will be invaluable as we build on our research. We’re still analyzing the data, but we’re confident that we’ll gain new insights into disease mechanisms that will advance our research."

Wouter Peelaerts, PhDProfessor, KU Leuven

What Our Customers Are Saying

"CDI Labs provide consistent service and consistently high-quality protein array products to our lab. Their sales and scientific team are courteous and timely in their responses to our queries.”

Dr. Andrew McKeonMayo Clinic College of Medicine & Science

Data and Technology Validated by Scientists

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

OncologistSchool of Medicine Research (as mentioned in "Baseline Serum Autoantibody Signatures Predict Recurrence and Toxicity in Melanoma Patients Receiving Adjuvant Immune Checkpoint Blockade" - AACR Clinical Caner Research - September 2022)

Data and Technology Validated by Scientists

"This (VirScan) assay, which uses phage display immunoprecipitation and sequencing, is a sensitive and focused high-comprehensive approach that enables thorough serological profiling of antiviral antibodies in humans and, consequently, the identification of viral exposure throughout the human virome."

Faculty of MedicineResearch Institution (as mentioned in "Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8+ T cells in patients with advanced NSCLC" - Science Advances - November 2023)

Data and Technology Validated by Scientists

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Senior ScientistBiotech Research (poster presentation at the San Antonio Breast Cancer Symposium 2023)

Related Resources

Content

ZIP | 23.81 MB

VirScan PhIP-Seq Content

Proteomes of all vertebrate viruses are included for VirScan™ autoantibody testing. ZIP file containing .csv...

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Publication

Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent...

Circulating senescent CD8+ T (T8sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in...

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Publication

Reduced anti-viral IgG repertoire in HIV-exposed but uninfected infants compared to HIV-unexposed...

Infants who are HIV exposed but uninfected (iHEU) have higher risk of viral infections compared to infants who are HIV unexposed (iHUU). We explored the effect of intrauterine HIV exposure on the...

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Publication

Primary oxidative phosphorylation defects lead to perturbations in the human B cell...

The majority of studies on oxidative phosphorylation in immune cells have been performed in mouse models, necessitating human translation. To understand the impact of oxidative phosphorylation...

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Technology

Overview of VirScan™ Viral Proteome Phage...

This video / animation is a short overview of the CDI Labs VirScan™ Viral Proteome Phage Display product and...

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Technology

Overview of Autoantibody Seromics

This video / animation is a short overview of CDI Labs Autoantibody...

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Events

Seromics: A New Frontier of Immune Biomarkers and Druggable Target...

It is already clear that each individual’s serome is incredibly unique, complex, and yet accessible via proteome microarrays (HuProt), phage-display immunoprecipitation sequencing (PhIP-Seq,...

Advanced High-throughput Viral Antibody Profiling

Viral Exposure Profiling and Pathogen Surveillance

Phage Display ImmunoPrecipitation Sequencing (PhIP-Seq) is a powerful method of multiplexed analysis that combines DNA high-throughput sequencing with next-gen proteomics.

VirScan® PhIP-Seq Advantages

Enabling researcher to uncover both individual and population-level histories of viral infections

VirScan Technology Overview

Ready to Transform Your Research?

What Our Customers Are Saying

"With CDI Labs, identifying antibodies and their targets has never been so simple. Their passionate team, robust science and high-quality service unlock the discovery of new mechanisms, biomarkers and therapeutic targets."

What Our Customers Are Saying

What Our Customers Are Saying

"CDI Labs provide consistent service and consistently high-quality protein array products to our lab. Their sales and scientific team are courteous and timely in their responses to our queries.”

Data and Technology Validated by Scientists

"We elected to use the HuProt Microarray because it is an extensive platform that contains over 21,000 unique, individually purified full-length human proteins and protein isoforms in duplicate, covering more than 81% of the proteome."

Data and Technology Validated by Scientists

Data and Technology Validated by Scientists

"By using (HuProt) protein arrays, we were able to evaluate a broader range of antigens compared to previous investigations."

Related Resources

VirScan PhIP-Seq Content

Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent...

Reduced anti-viral IgG repertoire in HIV-exposed but uninfected infants compared to HIV-unexposed...

Primary oxidative phosphorylation defects lead to perturbations in the human B cell...

Overview of VirScan™ Viral Proteome Phage...

Overview of Autoantibody Seromics

Seromics: A New Frontier of Immune Biomarkers and Druggable Target...

Study Report Overview: PhIP-Seq and Seromics